Estraval Depot (Estradiol Valerate) 10 mg/ml 10 ampules

Manufacturer: Actiza Pharmaceutical Ltd (India)

Indications for use

Estraval Depot is used for the treatment of:

- Amenorrhea (absence of menstruation)

- Menstrual disorders (for example, rare or frequent menstruation)

- Irregularities in the volume of menstruation (for example, scant or heavy bleeding)

- Dysmenorrhea (painful menstruation)

- Functional uterine bleeding

- Uterine hypoplasia (underdevelopment of the uterus)

- Symptoms of ovarian insufficiency

- Disorders during menopause

- Infertility

Method of application and dosage

- Method of application: intramuscular injection

- Dosage: 5-10 mg of estradiol valerate once every 1-4 weeks.

- Correction: The dosage can be adjusted depending on the symptoms and recommendations of the doctor.

Warnings and precautions

Consult your doctor before using this medication if:

1. You have a history of allergic reactions (for example, itching, rash) to medications.

2. You have kidney failure.

3. You are pregnant or breastfeeding.

4. You are taking other medications (risk of drug interactions).

Contraindications

This drug is not prescribed to patients with:

1. Estrogen-dependent malignancies (for example, breast cancer, endometrial cancer).

2. History of breast cancer (risk of recurrence).

3. Endometrial hyperplasia without treatment (risk of cellular atypia).

4. Thrombophlebitis, pulmonary embolism, or a history of these diseases.

5. Arterial thromboembolism (for example, coronary artery disease, stroke) or a history of these diseases.

6. Severe liver diseases (may worsen due to decreased metabolism).

7. Undiagnosed abnormal genital bleeding (risk of exacerbation of endometrial cancer).

Pregnancy and lactation

- Pregnancy: Contraindicated. Estrogens can harm the fetus.

- Lactation period: Contraindicated. Estrogens can enter breast milk and have an effect on the baby.

Storage Instructions

- Store in a dark, dry and cool place.

- Keep the product away from direct sunlight and out of the reach of children.

Important instructions

- Always follow the doctor's instructions regarding the dosage and administration of the drug.

- Report any side effects (e.g. allergic reactions, unusual bleeding) to your doctor immediately.

- Do not take this medication if you have any of the contraindications listed above.

For more information, consult your doctor or pharmacist.

Treatment of transgender people with Estraval Depot

Estraval Depot (estradiol valerate) is a synthetic estrogenic drug widely used in hormone therapy for transgender women (MtF) and others in need of feminizing hormone therapy. It is one of the most common estradiol esters, which is used to suppress male secondary sexual characteristics and stimulate the development of female characteristics such as breast growth, fat redistribution and a decrease in testosterone levels.