Penicillamine 250 mg 50 capsules

Cilamin 250 mg (active ingredient: Penicillamine) is a prescription drug from the group of complexing compounds. It is not a common analgesic or anti-inflammatory agent, but is used to treat specific, often severe diseases associated with metabolic disorders or autoimmune processes.

Indications for use

Cilamin is prescribed by a doctor strictly according to the indications for the treatment of the following diseases:

Wilson-Konovalov disease (hepatolenticular degeneration): It is a rare genetic disease in which excess copper accumulates in the body, leading to severe damage to the liver and nervous system. The drug binds copper and removes it in the urine.

Severe active rheumatoid arthritis: Used in cases where other basic anti-inflammatory drugs have failed. Cilamin slows down the progression of the disease and the destruction of joints.

Cystinuria and cystine kidney stones: A hereditary disease in which cystine stones form in the kidneys. The drug binds the amino acid cystine, making it more soluble and preventing the formation of stones.

Heavy metal poisoning: Used as an antidote for poisoning with lead, mercury, copper, zinc, gold and other metals.

Method of application and dosage

Important: The dosage is always selected by the doctor individually and depends on the disease and the patient's response to treatment.

How to take: The drug is taken orally, strictly on an empty stomach — at least 1 hour before or 2 hours after meals, and also not earlier than 1 hour after taking any other medications or food. This is necessary for proper absorption of the drug.

Typical dosing regimens:

In case of Wilson-Konovalov's disease: For adults, the daily dose is usually 0.75–1.5 g, divided into several doses. Effectiveness is assessed by the amount of copper excreted in the urine.

For rheumatoid arthritis: Treatment begins with a low dose (125-250 mg per day), gradually increasing it by 125 mg every 1-2 months. The effect usually occurs no earlier than after 3 months of continuous use.

For cystinuria: The daily dose for adults is on average 2 g, divided into 4 doses. It is important to consume a large amount of liquid (at least 0.5 liters before bedtime and at night).

Contraindications

Hypersensitivity to penicillamine or any component of the drug .

Severe hematopoiesis disorders (e.g. aplastic anemia, agranulocytosis) in the anamnesis.

Chronic renal failure .

Pregnancy (with the exception of Wilson's disease, when the potential benefit outweighs the risk to the fetus) and breastfeeding.

Simultaneous use with gold preparations, antimalarial drugs, cytostatics, oxyphenbutazone .

Side effects

Cilamine can cause serious side effects, so treatment requires careful medical supervision.

Common side effects: Loss or distortion of taste, loss of appetite, nausea, vomiting, diarrhea, abdominal pain, stomatitis.

Serious side effects (require immediate medical attention):

From the blood: Decreased number of white blood cells, platelets, anemia, which can manifest as fever, sore throat, bleeding, bruising.

On the part of the kidneys: The appearance of protein or blood in the urine, nephritis .

From the lungs: Shortness of breath, cough, pneumonitis.

Allergic reactions: Skin rash, itching, urticaria, fever.

Others: Muscle weakness, tinnitus, visual impairment.

Special instructions and precautions

Medical monitoring: Regular blood (general clinical) and urine tests should be performed throughout the course of treatment. In the first 6 months, tests are performed every 2 weeks, then monthly. Liver and kidney function monitoring is also necessary.

Interaction with other substances:

Iron, zinc, magnesium, and aluminum preparations (contained in antacids), as well as milk, reduce the absorption of Cilamin. The interval between their intake should be at least 2 hours.

Simultaneous intake of vitamin B6 (pyridoxine) at a dose of 25 mg per day is recommended for the prevention of neurological complications.

Pregnancy and lactation: The drug is contraindicated during pregnancy (category D of action on the fetus according to the FDA) and during lactation