Dicorate ER 500 (Divalproex Sodium) 500 mg 100 tablets

Dicorate ER 500 (Divalproex Sodium) 500 mg extended-release tablets, 100 tablets — Sun Pharmaceutical Industries

Dicorate ER 500 is a prescription-only anticonvulsant and mood stabiliser from India. Each extended-release film-coated tablet contains 500 mg of divalproex sodium (a compound of sodium valproate and valproic acid). The pack holds 10 strips of 10 tablets — 100 tablets in total — and is manufactured by Sun Pharmaceutical Industries Ltd., India. Divalproex sodium is used under medical supervision for epilepsy, bipolar disorder and prevention of migraine attacks.

Product overview

• Trade name: Dicorate ER 500
• Active ingredient: Divalproex sodium 500 mg (sodium valproate + valproic acid, equivalent to valproic acid)
• Strength: 500 mg per tablet
• Dosage form: Extended-release film-coated tablets for oral use
• Pack size: 10 x 10 tablets (100 tablets)
• Manufacturer: Sun Pharmaceutical Industries Ltd.
• Country of origin: India
• Product category: Medicines from India
• Prescription status: Prescription only (Rx) — dispensing and use require a physician's prescription

What divalproex sodium is used for

Divalproex sodium belongs to the group of valproate medicines, which act on the central nervous system. Doctors prescribe it for:

• epilepsy — complex partial seizures, simple and complex absence seizures, and generalised seizures, alone or together with other anticonvulsants;
• bipolar disorder — treatment of acute manic or mixed episodes;
• prophylaxis of migraine headaches in adults.

The decision to prescribe this medicine, and the choice between valproate medicines, is made by a physician based on the diagnosis, medical history and other treatment already in use.

How it is used

Divalproex sodium is a prescription medicine. The dose is selected and adjusted individually by the treating physician, and blood tests are used to monitor the medicine during treatment. Extended-release tablets are swallowed whole — they are not crushed, chewed or split, because this changes how the active substance is released. The medicine is not started, stopped or re-dosed on one's own: abrupt withdrawal can provoke seizures.

Possible side effects

Common effects reported during treatment include nausea, stomach discomfort, tremor, drowsiness, dizziness, changes in body weight, hair thinning and menstrual irregularities. Serious, less common effects include liver injury, inflammation of the pancreas (pancreatitis), changes in blood cell counts, raised ammonia levels with confusion, and severe skin reactions. Any unusual weakness, persistent vomiting, yellowing of the skin or eyes, dark urine, bleeding, or worsening drowsiness requires immediate medical attention.

Important precautions

• Prescription only: not for self-medication, not to be shared with other people, and not to be started without a physician.
• Valproate medicines carry a risk of serious harm to an unborn child (neural tube defects and developmental disorders). Pregnancy, planning of pregnancy and breastfeeding must be discussed with the prescribing physician before treatment.
• Regular monitoring of liver function, blood cell counts and clinical condition is required during treatment.
• Treatment must not be interrupted abruptly; any change is made by the physician.
• Tell the doctor about all other medicines in use — anticonvulsants, aspirin, warfarin-type anticoagulants and some antibiotics can interact with divalproex sodium.
• Alcohol and other medicines acting on the nervous system increase drowsiness; discuss them with the physician.
• Children, elderly patients and people with liver disease need separate specialist assessment.

Storage and packaging

Store below 25-30 °C in a dry place, protected from light and moisture, in the original packaging with the strip inside. Keep out of reach of children. Do not use after the expiry date printed on the pack.

Important notice

The photographs and information on this page are provided for product identification and general reference. They do not replace the patient information leaflet, the advice of a physician or a pharmacist, and they are not a recommendation to use the medicine. Dicorate ER 500 is a prescription-only medicine; treatment is started and supervised by a doctor.

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